Ontology highlight
ABSTRACT:
SUBMITTER: Feinberg AW
PROVIDER: S-EPMC3841251 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Feinberg Adam W AW Ripplinger Crystal M CM van der Meer Peter P Sheehy Sean P SP Domian Ibrahim I Chien Kenneth R KR Parker Kevin Kit KK
Stem cell reports 20131107 5
Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which stem cell-derived cardiomyocytes compare to mature cardiomyocytes is often debated. We reasoned that physiological metrics of engineered cardiac tissues offer a means of comparison. We built laminar myocardium engineered from cardiomyocytes that were differentiated from mouse embryon ...[more]