Ontology highlight
ABSTRACT:
SUBMITTER: Orte A
PROVIDER: S-EPMC2567173 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Orte Angel A Birkett Neil R NR Clarke Richard W RW Devlin Glyn L GL Dobson Christopher M CM Klenerman David D
Proceedings of the National Academy of Sciences of the United States of America 20080916 38
A key issue in understanding the pathogenic conditions associated with the aberrant aggregation of misfolded proteins is the identification and characterization of species formed during the aggregation process. Probing the nature of such species has, however, proved to be extremely challenging to conventional techniques because of their transient and heterogeneous character. We describe here the application of a two-color single-molecule fluorescence technique to examine the assembly of oligomer ...[more]