Ontology highlight
ABSTRACT:
SUBMITTER: Chicka MC
PROVIDER: S-EPMC2570314 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Chicka Michael C MC Hui Enfu E Liu Huisheng H Chapman Edwin R ER
Nature structural & molecular biology 20080711 8
Neuronal communication is mediated by Ca(2+)-triggered fusion of transmitter-filled synaptic vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca(2+) sensor that regulates exocytosis, whereas soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins in the vesicle and target membrane assemble into complexes that directly catalyze bilayer fusion. Here we report that, before the Ca(2+) trigger, synaptotagmin interacts with SNARE prote ...[more]