Ontology highlight
ABSTRACT:
SUBMITTER: Roa S
PROVIDER: S-EPMC2571010 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Roa Sergio S Avdievich Elena E Peled Jonathan U JU Maccarthy Thomas T Werling Uwe U Kuang Fei Li FL Kan Rui R Zhao Chunfang C Bergman Aviv A Cohen Paula E PE Edelmann Winfried W Scharff Matthew D MD
Proceedings of the National Academy of Sciences of the United States of America 20081014 42
Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties of proliferating cell nuclear antigen (PCNA) and ubiquitylation of its residue K164 have been suggested to play an important role organizing the error-prone repair events that contribute to the AID-induced diversification of the Ig locus. We generated knockout mice for PCNA (Pcna(-/-)), which were embryonic letha ...[more]