Ontology highlight
ABSTRACT:
SUBMITTER: Reina-San-Martin B
PROVIDER: S-EPMC2193951 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Reina-San-Martin Bernardo B Difilippantonio Simone S Hanitsch Leif L Masilamani Revati F RF Nussenzweig Andre A Nussenzweig Michel C MC
The Journal of experimental medicine 20030601 12
Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic function. Phosphorylation of histone H2AX promotes DNA repair and helps maintain genomic stability. Although B cells lacking H2AX show impaired class switch recombination (CSR), the precise role of H2AX in CSR and somatic hypermutation (SHM) has not been defined. We show that H2AX is not required for SHM, suggesting that the processing of DNA lesions leading to SHM is fundame ...[more]