Ontology highlight
ABSTRACT:
SUBMITTER: Casal E
PROVIDER: S-EPMC2572078 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Casal Eva E Federici Luca L Zhang Wei W Fernandez-Recio Juan J Priego Eva-Maria EM Miguel Ricardo Nuñez RN DuHadaway James B JB Prendergast George C GC Luisi Ben F BF Laue Ernest D ED
Biochemistry 20061001 43
BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution. Both the quaternary and tertiary architectures of the homodimeric Bin1BAR domain are built upon "knobs-into-holes" packing of side chains, like those found in conventional left-handed coiled-coils, and this packing governs the curvature of a putative membrane-engaging conca ...[more]