Ontology highlight
ABSTRACT:
SUBMITTER: le Viseur C
PROVIDER: S-EPMC2572185 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20080701 1
We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was transplanted intrafemorally into NOD/scid mice. Cells sorted using the B precursor differentiation markers CD19, CD20, and CD34 were isolated from patient samples and engrafted mice before serial transplantation into primary or subsequent (up to quaternary) recipients. Surprisingly, blasts representative of all of the different m ...[more]