Halogenated cyclic peptides isolated from the sponge Corticium sp.

ABSTRACT: Fractionation of two Fijian specimens of the sponge Corticium sp. led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2). Structural elucidation of 1 and 2 was achieved by an extensive combination of high-field NMR and HRFT MS/MS experiments, and the absolute stereochemistry of 2 was determined by acid hydrolysis and Marfey's analysis. Corticiamide A (1) and cyclocinamide B (2) represent the first peptides to be described from the genus Corticium.

SUBMITTER: Laird DW 

PROVIDER: S-EPMC2533844 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature