Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC2574800 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20080817 18
Molecules that target microtubules have an important role in the treatment of cancer. A new class of inhibitors of tubulin polymerization based on the 2-(3,4,5-trimethoxybenzoyl)-2-dimethylamino-benzo[b]furan molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. The most promising compound in this series was 2-(3,4,5-trimethoxybenzoyl)-3-dimethylamino-6-methoxy-benzo[b]furan, which inhibits cancer cell growt ...[more]