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ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC2762272 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20090820 19
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthes ...[more]