Ontology highlight
ABSTRACT:
SUBMITTER: Wang WL
PROVIDER: S-EPMC2577330 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Wang Wen-Ling WL Lee Yi-Chao YC Yang Wen-Ming WM Chang Wen-Chang WC Wang Ju-Ming JM
Nucleic acids research 20080927 19
CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. In this study, the EGF-induced increase of CEBPB mRNA is shown to be coincident with the decrease of COX-2 mRNA. We identified that all of the individual CEBPB isoforms, LAP1, LAP2 and LIP, attenuate EGF-induced COX-2 promoter activity. Although increased sumoylation of both LAP1 and LAP2 is observed during the lagging stage of EGF treatment, only the ...[more]