Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh TK
PROVIDER: S-EPMC6884511 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ghosh Tushar K TK Aparicio-Sánchez José J JJ Buxton Sarah S Brook J David JD
Scientific reports 20191129 1
TBX5 is a T-box family transcription factor that regulates heart and forelimb development in vertebrates and functional deficiencies in this protein result in Holt-Oram syndrome. Recently, we have shown that acetylation of TBX5 potentiates its activity and is important for heart and limb development. Here we report that class II histone deacetylases HDAC4 and HDAC5 associate with TBX5 and repress its role in cardiac gene transcription. Both HDAC4 and HDAC5 deacetylate TBX5, which promotes its re ...[more]