Ontology highlight
ABSTRACT:
SUBMITTER: Lefevre P
PROVIDER: S-EPMC2581490 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lefevre Pascal P Witham James J Lacroix Claire E CE Cockerill Peter N PN Bonifer Constanze C
Molecular cell 20081001 1
Transcription of the lysozyme gene is rapidly induced by proinflammatory stimuli such as treatment with bacterial lipopolysaccharide (LPS). Here we show that this induction involves both the relief of repression mediated by the enhancer-blocking protein CTCF that binds to a negative regulatory element at -2.4 kb, and the activation of two flanking enhancer elements. The downstream enhancer has promoter activity, and LPS stimulation initiates the transient synthesis of a noncoding RNA (LINoCR) tr ...[more]