Ontology highlight
ABSTRACT:
SUBMITTER: Hewitt SL
PROVIDER: S-EPMC2583163 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Hewitt Susannah L SL Farmer Deborah D Marszalek Katarzyna K Cadera Emily E Liang Hong-Erh HE Xu Yang Y Schlissel Mark S MS Skok Jane A JA
Nature immunology 20080224 4
Variable-(diversity)-joining (V(D)J) recombination at loci encoding the immunoglobulin heavy chain (Igh) and immunoglobulin light chain (Igk) takes place sequentially during successive stages in B cell development. Using three-dimensional DNA fluorescence in situ hybridization, here we identify a lineage-specific and stage-specific interchromosomal association between these two loci that marks the transition between Igh and Igk recombination. Colocalization occurred between pericentromerically l ...[more]