Ontology highlight
ABSTRACT:
SUBMITTER: Qiu X
PROVIDER: S-EPMC6003238 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20180322 1
Immunoglobulin heavy-chain (IgH) genes are assembled by DNA rearrangements that juxtapose a variable (V<sub>H</sub>), a diversity (D<sub>H</sub>), and a joining (J<sub>H</sub>) gene segment. Here, we report that in the absence of intergenic control region 1 (IGCR1), the intronic enhancer (Eμ) associates with the next available CTCF binding site located close to V<sub>H</sub>81X via putative heterotypic interactions involving YY1 and CTCF. The alternate Eμ/V<sub>H</sub>81X loop leads to formation ...[more]