An evolutionary history of P2X receptors.
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ABSTRACT:
SUBMITTER: Fountain SJ
PROVIDER: S-EPMC2717308 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
An evolutionary history of P2X receptors.
Fountain Samuel J SJ Burnstock Geoffrey G
Purinergic signalling 20081118 3
Adenosine triphosphate (ATP) is an ancient and fundamentally important biological molecule involved in both intracellular and extracellular activities. P2X ionotropic and P2Y metabotropic receptors have been cloned and characterised in mammals. ATP plays a central physiological role as a transmitter molecule in processes including the sensation of pain, taste, breathing and inflammation via the activation of P2X receptors. P2X receptors are structurally distinct from glutamate and Cys-loop/nicot ...[more]
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