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Layer-by-layer films from hyaluronan and amine-modified hyaluronan.

ABSTRACT: Hyaluronan is a polysaccharide that is increasingly investigated for its role in cellular adhesion and for the preparation of biomimetic matrices for tissue engineering. Hyaluronan gels are prepared for application as space fillers, whereas hyaluronan films are usually obtained by adsorbing or grafting a single hyaluronan layer onto a biomaterial surface. Here, we examine the possibility to employ the layer-by-layer technique to deposit thin films of cationic-modified hyaluronan (HA+) and hyaluronan (HA) of controlled thicknesses. The buildup conditions are investigated, and growth is compared to that of other polyelectrolyte multilayer films containing either HA as the polyanion or HA+ as the polycation. The films could be formed in a low ionic strength medium but are required to be cross-linked prior to contact with a physiological medium. NIH3T3 fibroblasts were perfectly viable on self-assembled hyaluronan films with, however, a preference for hyaluronan ending films. These findings point out the possibility to tune the thickness of thin hyaluronan films at the nanometer scale. Such architectures could be employed for investigating cell/substrate interactions or for functionalizing biomaterial surfaces.

SUBMITTER: Schneider A

PROVIDER: S-EPMC2585505 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Layer-by-layer films from hyaluronan and amine-modified hyaluronan.

Schneider Aurore A Picart Catherine C Picart Catherine C Senger Bernard B Schaaf Pierre P Voegel Jean-Claude JC Frisch Benoit B

Langmuir : the ACS journal of surfaces and colloids 20070201 5

Hyaluronan is a polysaccharide that is increasingly investigated for its role in cellular adhesion and for the preparation of biomimetic matrices for tissue engineering. Hyaluronan gels are prepared for application as space fillers, whereas hyaluronan films are usually obtained by adsorbing or grafting a single hyaluronan layer onto a biomaterial surface. Here, we examine the possibility to employ the layer-by-layer technique to deposit thin films of cationic-modified hyaluronan (HA+) and hyalur ...[more]

PMID: 17309215

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Project description:Exceptional electrical conductivity and abundance of surface terminations like-F- and OH- leading to hydrophilicity make the family of 2D transition metal carbides/nitrides and carbonitrides (MXene) excellent candidates for energy storage and conversion applications. MXenes, however, undergo restacking of nanosheets via van der Waals interaction, hindering the active sites, leading to slow electronic and ionic kinetics, and ultimately affecting their electrochemical performance. Herein, we report binder-free cetyltrimethylammonium bromide-reduced graphene oxide (CTAB-rGO)-modified MXene hybrid films on nickel foam as a promising noble metal-free multifunctional electrode synthesized via layer-by-layer assembly and dip coating techniques, which effectively reduce restacking while improving the kinetics. The properties of the as-prepared electrocatalysts are investigated using various physiochemical characterizations and electrochemical measurements to accomplish the objective of "creating one kind of electrocatalyst for multiapplication" with a thorough understanding of the relationship between the material structure, morphology, and electrocatalytic performance. In energy conversion, the synergetic effect of MXene and the CTAB-rGO support helped increase the catalytic activity of the composite for electrochemical water splitting, demonstrating a current density of 10 mA/cm2 at an overpotential (η) of 360 V and a Tafel slope value of 56.6 mV/dec for hydrogen evolution reaction and a current density of 10 mA/cm2 at an overpotential (η) of 179 mV and a Tafel slope value of 47.03 mV/dec for oxygen evolution reaction in an alkaline medium. The electrode material also exhibited a higher oxidation current density (373.60 mA/cm2) compared to that of synthesized MXene toward methanol oxidation reaction in direct methanol fuel cell application. Additionally, the energy storage potential of CTAB-rGO modified MXene as electrode materials for supercapacitors with a high specific capacitance (544.50 F g-1 at 0.5 A g-1) and a good capacity retention of 87% after 5000 cycles was studied. These findings of this work showcase the potential of the electrocatalyst in both conversion and storage of electrochemical energy.

Dataset Information

Layer-by-layer films from hyaluronan and amine-modified hyaluronan.

Publications

Layer-by-layer films from hyaluronan and amine-modified hyaluronan.

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