Ontology highlight
ABSTRACT:
SUBMITTER: Koushika SP
PROVIDER: S-EPMC2585766 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Nature neuroscience 20011001 10
Rim1 was previously identified as a Rab3 effector localized to the presynaptic active zone in vertebrates. Here we demonstrate that C. elegans unc-10 mutants lacking Rim are viable, but exhibit behavioral and physiological defects that are more severe than those of Rab3 mutants. Rim is localized to synaptic sites in C. elegans, but the ultrastructure of the presynaptic densities is normal in Rim mutants. Moreover, normal levels of docked synaptic vesicles were observed in mutants, suggesting tha ...[more]