Endocannabinoids and the control of energy homeostasis.
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ABSTRACT:
SUBMITTER: Kunos G
PROVIDER: S-EPMC2586261 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Endocannabinoids and the control of energy homeostasis.
Kunos George G Osei-Hyiaman Douglas D Liu Jie J Godlewski Gregorz G Bátkai Sándor S
The Journal of biological chemistry 20080811 48
Endocannabinoids (ECBs) are ubiquitous lipid mediators that act through the same G protein-coupled receptors (CB1 and CB2) that recognize plant-derived cannabinoids. As regulators of metabolism, ECBs are anabolic: they increase the intake, promote the storage, and decrease the expenditure of energy. Recent work indicates that activation of peripheral CB1 receptors by ECBs plays a key role in the hormonal/metabolic changes associated with obesity/metabolic syndrome and may be targeted for its pha ...[more]
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