Ontology highlight
ABSTRACT:
SUBMITTER: Luo S
PROVIDER: S-EPMC2586976 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Luo Shiwen S Zhang Bin B Dong Xian-Ping XP Tao Yanmei Y Ting Annie A Zhou Zheng Z Meixiong James J Luo Junjie J Chiu F C Alex FC Xiong Wen C WC Mei Lin L
Neuron 20081001 1
Rapsyn, an acetylcholine receptor (AChR)-interacting protein, is essential for synapse formation at the neuromuscular junction (NMJ). Like many synaptic proteins, rapsyn turns over rapidly at synapses. However, little is known about molecular mechanisms that govern rapsyn stability. Using a differential mass-spectrometry approach, we identified heat-shock protein 90beta (HSP90beta) as a component in surface AChR clusters. The HSP90beta-AChR interaction required rapsyn and was stimulated by agrin ...[more]