Ontology highlight
ABSTRACT:
SUBMITTER: Firestein R
PROVIDER: S-EPMC2587138 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Firestein Ron R Bass Adam J AJ Kim So Young SY Dunn Ian F IF Silver Serena J SJ Guney Isil I Freed Ellen E Ligon Azra H AH Vena Natalie N Ogino Shuji S Chheda Milan G MG Tamayo Pablo P Finn Stephen S Shrestha Yashaswi Y Boehm Jesse S JS Jain Supriya S Bojarski Emeric E Mermel Craig C Barretina Jordi J Chan Jennifer A JA Baselga Jose J Tabernero Josep J Root David E DE Fuchs Charles S CS Loda Massimo M Shivdasani Ramesh A RA Meyerson Matthew M Hahn William C WC
Nature 20080914 7212
Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To identify genes that both modulate beta-catenin activity and are essential for colon cancer cell proliferation, we conducted two loss-of-function screens in human colon cancer cells ...[more]