Ontology highlight
ABSTRACT:
SUBMITTER: Ma YC
PROVIDER: S-EPMC2587148 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Ma Yong-Chao YC Song Mi-Ryoung MR Park Jin P JP Henry Ho Hsin-Yi HY Hu Linda L Kurtev Martin V MV Zieg Janine J Ma Qiufu Q Pfaff Samuel L SL Greenberg Michael E ME
Neuron 20080401 1
The mechanisms by which proneural basic helix-loop-helix (bHLH) factors control neurogenesis have been characterized, but it is not known how they specify neuronal cell-type identity. Here, we provide evidence that two conserved serine residues on the bHLH factor neurogenin 2 (Ngn2), S231 and S234, are phosphorylated during motor neuron differentiation. In knockin mice in which S231 and S234 of Ngn2 were mutated to alanines, neurogenesis occurs normally, but motor neuron specification is impaire ...[more]