Ontology highlight
ABSTRACT:
SUBMITTER: Sun A
PROVIDER: S-EPMC2587337 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Sun Aiming A Yoon Jeong-Joong JJ Yin Yan Y Prussia Andrew A Yang Yutao Y Min Jaeki J Plemper Richard K RK Snyder James P JP
Journal of medicinal chemistry 20080605 13
Measles virus (MV) is one of the most infectious pathogens known. In spite of the existence of a vaccine, approximately 350000 deaths/year result from MV or associated complications. Antimeasles compounds could conceivably diminish these statistics and provide a therapy that complements vaccine treatment. We recently described a high-throughput screening hit compound 1 (16677) against MV-infected cells with the capacity to eliminate viral reproduction at 250 nM by inhibiting the action of the vi ...[more]