Ontology highlight
ABSTRACT:
SUBMITTER: Qin S
PROVIDER: S-EPMC3240845 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Qin Sanbo S Pang Xiaodong X Zhou Huan-Xiang HX
Structure (London, England : 1993) 20111201 12
The association rate constants (k(a)) of proteins with other proteins or other macromolecular targets are a fundamental biophysical property. Observed rate constants span over ten orders of magnitude, from 1 to 10(10) M(-1)s(-1). Protein association can be rate limited either by the diffusional approach of the subunits to form a transient complex, with near-native separation and orientation but without short-range native interactions, or by the subsequent conformational rearrangement to form the ...[more]