Ontology highlight
ABSTRACT:
SUBMITTER: Lee HH
PROVIDER: S-EPMC2720046 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20081001 5901
The ESCRT (endosomal sorting complex required for transport) machinery is required for the scission of membrane necks in processes including the budding of HIV-1 and cytokinesis. An essential step in cytokinesis is recruitment of the ESCRT-I complex and the ESCRT-associated protein ALIX to the midbody (the structure that tethers two daughter cells) by the protein CEP55. Biochemical experiments show that peptides from ALIX and the ESCRT-I subunit TSG101 compete for binding to the ESCRT and ALIX-b ...[more]