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A map of the interactome network of the metazoan C. elegans.

ABSTRACT: To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.

SUBMITTER: Li S 

PROVIDER: S-EPMC1698949 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature

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A map of the interactome network of the metazoan C. elegans.

Li Siming S   Armstrong Christopher M CM   Bertin Nicolas N   Ge Hui H   Milstein Stuart S   Boxem Mike M   Vidalain Pierre-Olivier PO   Han Jing-Dong J JD   Chesneau Alban A   Hao Tong T   Goldberg Debra S DS   Li Ning N   Martinez Monica M   Rual Jean-François JF   Lamesch Philippe P   Xu Lai L   Tewari Muneesh M   Wong Sharyl L SL   Zhang Lan V LV   Berriz Gabriel F GF   Jacotot Laurent L   Vaglio Philippe P   Reboul Jérôme J   Hirozane-Kishikawa Tomoko T   Li Qianru Q   Gabel Harrison W HW   Elewa Ahmed A   Baumgartner Bridget B   Rose Debra J DJ   Yu Haiyuan H   Bosak Stephanie S   Sequerra Reynaldo R   Fraser Andrew A   Mango Susan E SE   Saxton William M WM   Strome Susan S   Van Den Heuvel Sander S   Piano Fabio F   Vandenhaute Jean J   Sardet Claude C   Gerstein Mark M   Doucette-Stamm Lynn L   Gunsalus Kristin C KC   Harper J Wade JW   Cusick Michael E ME   Roth Frederick P FP   Hill David E DE   Vidal Marc M  

Science (New York, N.Y.) 20040102 5657

To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2  ...[more]

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