Ontology highlight
ABSTRACT:
SUBMITTER: Roeder I
PROVIDER: S-EPMC2597595 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Roeder Ingo I Horn Katrin K Sieburg Hans-Bernd HB Cho Rebecca R Muller-Sieburg Christa C Loeffler Markus M
Blood 20080922 13
Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell-based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, which are based on the analysis of limiting dilution competitive repopulation experiments in mice, demonstrate that small quantitative but clonally fixed differences of cellular properties are necessary ...[more]