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A concise synthesis of the cortistatin core.

ABSTRACT: We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to the development of a SAR program based on diverted total synthesis.

SUBMITTER: Dai M

PROVIDER: S-EPMC2598409 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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A concise synthesis of the cortistatin core.

Dai Mingji M Danishefsky Samuel J SJ

Tetrahedron letters 20081101 47

We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to the development of a SAR program based on diverted total synthesis. ...[more]

PMID: 19924219

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