Unknown

Dataset Information

0

Concise synthesis of capuramycin.

ABSTRACT: A concise total synthesis of capuramycin (1), a promising preclinical TB drug lead, is achieved by high-yield formations of the cyanohydrin 5a and 4'',5''-glycal derivative 12. Capuramycin can be synthesized in eight steps from the uridine building block 5a with >30% overall yield. The synthetic intermediates reported here are useful for generation of analogs to improve pharmacokinetic properties of capuramycin.

SUBMITTER: Kurosu M 

PROVIDER: S-EPMC4784474 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Concise synthesis of capuramycin.

Kurosu Michio M   Li Kai K   Crick Dean C DC  

Organic letters 20090601 11

A concise total synthesis of capuramycin (1), a promising preclinical TB drug lead, is achieved by high-yield formations of the cyanohydrin 5a and 4'',5''-glycal derivative 12. Capuramycin can be synthesized in eight steps from the uridine building block 5a with >30% overall yield. The synthetic intermediates reported here are useful for generation of analogs to improve pharmacokinetic properties of capuramycin. ...[more]

Similar Datasets

Unknown Concise synthesis of (+)-fastigiatine.
| S-EPMC5580306 | biostudies-literature
Unknown Concise Synthesis of Broussonone A.
| S-EPMC6331890 | biostudies-other
Unknown Concise Synthesis of Tetrazole Macrocycle.
| S-EPMC5633831 | biostudies-literature
Unknown Concise Synthesis of Functionalized Benzocyclobutenones.
| S-EPMC4049219 | biostudies-literature
Unknown A concise synthesis of carolacton.
| S-EPMC3993612 | biostudies-literature
Unknown Concise asymmetric synthesis of (-)-bilobalide.
| S-EPMC7017908 | biostudies-literature
Unknown A Concise Total Synthesis of (±)-Vibralactone.
| S-EPMC6351154 | biostudies-literature
Unknown A concise synthesis of (-)-lasonolide A.
| S-EPMC3939832 | biostudies-literature
Unknown A concise synthesis of ent-Cholesterol.
| S-EPMC2729551 | biostudies-literature
Unknown Concise total synthesis of (±)-actinophyllic acid.
| S-EPMC4034156 | biostudies-literature