Concise synthesis of (+)-fastigiatine.

ABSTRACT: (+)-Fastigiatine was assembled in six steps from (R)-5-methylcyclohex-2-en-1-one. Intermolecular Diels-Alder reaction introduced most of the carbon atoms for the target. The two Boc-protected nitrogen atom building blocks were introduced by a Suzuki coupling and a cuprate addition. A biomimetic transannular Mannich reaction generated the two quaternary centers at a late stage. Each step builds core bonds, and combined with a minimalist protecting group strategy, this approach led to a very concise synthesis.

SUBMITTER: Samame RA 

PROVIDER: S-EPMC5580306 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature