Molecular mechanism for the umami taste synergism.
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ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC2606899 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Molecular mechanism for the umami taste synergism.
Zhang Feng F Klebansky Boris B Fine Richard M RM Xu Hong H Pronin Alexey A Liu Haitian H Tachdjian Catherine C Li Xiaodong X
Proceedings of the National Academy of Sciences of the United States of America 20081222 52
Umami is one of the 5 basic taste qualities. The umami taste of L-glutamate can be drastically enhanced by 5' ribonucleotides and the synergy is a hallmark of this taste quality. The umami taste receptor is a heteromeric complex of 2 class C G-protein-coupled receptors, T1R1 and T1R3. Here we elucidate the molecular mechanism of the synergy using chimeric T1R receptors, site-directed mutagenesis, and molecular modeling. We propose a cooperative ligand-binding model involving the Venus flytrap do ...[more]
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