Ontology highlight
ABSTRACT:
SUBMITTER: Gulbagci NT
PROVIDER: S-EPMC2613201 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Gulbagci Neriman Tuba NT Li Li L Ling Belinda B Gopinadhan Suma S Walsh Martin M Rossner Moritz M Nave Klaus-Armin KA Taneja Reshma R
EMBO reports 20081121 1
SHARP1, a basic helix-loop-helix transcription factor, is expressed in many cell types; however, the mechanisms by which it regulates cellular differentiation remain largely unknown. Here, we show that SHARP1 negatively regulates adipogenesis. Although expression of the early marker CCAAT/enhancer binding protein beta (C/EBPbeta) is not altered, its crucial downstream targets C/EBPalpha and peroxisome proliferator-activated receptor gamma (PPARgamma) are downregulated by SHARP1. Protein interact ...[more]