Ontology highlight
ABSTRACT:
SUBMITTER: Bournazou I
PROVIDER: S-EPMC2613454 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Bournazou Irini I Pound John D JD Duffin Rodger R Bournazos Stylianos S Melville Lynsey A LA Brown Simon B SB Rossi Adriano G AG Gregory Christopher D CD
The Journal of clinical investigation 20081201 1
Apoptosis is a noninflammatory, programmed form of cell death. One mechanism underlying the non-phlogistic nature of the apoptosis program is the swift phagocytosis of the dying cells. How apoptotic cells attract mononuclear phagocytes and not granulocytes, the professional phagocytes that accumulate at sites of inflammation, has not been determined. Here, we show that apoptotic human cell lines of diverse lineages synthesize and secrete lactoferrin, a pleiotropic glycoprotein with known antiinf ...[more]