Ontology highlight
ABSTRACT:
SUBMITTER: Frleta D
PROVIDER: S-EPMC3533550 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Frleta Davor D Ochoa Carolyn E CE Kramer Holger B HB Khan Shaukat Ali SA Stacey Andrea R AR Borrow Persephone P Kessler Benedikt M BM Haynes Barton F BF Bhardwaj Nina N
The Journal of clinical investigation 20121119 12
Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from ...[more]