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HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.


ABSTRACT: Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity.

SUBMITTER: Frleta D 

PROVIDER: S-EPMC3533550 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.

Frleta Davor D   Ochoa Carolyn E CE   Kramer Holger B HB   Khan Shaukat Ali SA   Stacey Andrea R AR   Borrow Persephone P   Kessler Benedikt M BM   Haynes Barton F BF   Bhardwaj Nina N  

The Journal of clinical investigation 20121119 12


Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from  ...[more]

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