Unknown

Dataset Information

0

A concise stereoselective synthesis of Preussin, 3-epi-Preussin, and analogues.


ABSTRACT: [reaction: see text] A new stereoselective synthesis of the antifungal and antitumor agents Preussin and 3-epi-Preussin via a Pd-catalyzed carboamination of a protected amino alcohol is described. The key transformation leads to simultaneous formation of the N-C2 bond and the C1'-aryl bond, and allows installation of the aryl group one step from the end of the sequence. This strategy permits the facile construction of a variety of preussin analogues bearing different aromatic groups.

SUBMITTER: Bertrand MB 

PROVIDER: S-EPMC2613785 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

A concise stereoselective synthesis of Preussin, 3-epi-Preussin, and analogues.

Bertrand Myra Beaudoin MB   Wolfe John P JP  

Organic letters 20060501 11


[reaction: see text] A new stereoselective synthesis of the antifungal and antitumor agents Preussin and 3-epi-Preussin via a Pd-catalyzed carboamination of a protected amino alcohol is described. The key transformation leads to simultaneous formation of the N-C2 bond and the C1'-aryl bond, and allows installation of the aryl group one step from the end of the sequence. This strategy permits the facile construction of a variety of preussin analogues bearing different aromatic groups. ...[more]

Similar Datasets

| S-EPMC2535798 | biostudies-literature
| S-EPMC5480354 | biostudies-literature
| S-EPMC3175814 | biostudies-literature
| S-EPMC6269118 | biostudies-literature
| S-EPMC6677407 | biostudies-literature
| S-EPMC4353025 | biostudies-literature
| S-EPMC7865922 | biostudies-literature
| S-EPMC4077357 | biostudies-literature
| S-EPMC9091711 | biostudies-literature
| S-EPMC3540812 | biostudies-literature