Ontology highlight
ABSTRACT:
SUBMITTER: Bertrand MB
PROVIDER: S-EPMC2613785 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Organic letters 20060501 11
[reaction: see text] A new stereoselective synthesis of the antifungal and antitumor agents Preussin and 3-epi-Preussin via a Pd-catalyzed carboamination of a protected amino alcohol is described. The key transformation leads to simultaneous formation of the N-C2 bond and the C1'-aryl bond, and allows installation of the aryl group one step from the end of the sequence. This strategy permits the facile construction of a variety of preussin analogues bearing different aromatic groups. ...[more]