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Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues.

ABSTRACT: A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

SUBMITTER: Tsvelikhovsky D

PROVIDER: S-EPMC3175814 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues.

Tsvelikhovsky Dmitry D Buchwald Stephen L SL

Journal of the American Chemical Society 20110822 36

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles. ...[more]

PMID: 21838278

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