Ontology highlight
ABSTRACT:
SUBMITTER: Lin MT
PROVIDER: S-EPMC2613806 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Lin Mike T MT Luján Rafael R Watanabe Masahiko M Adelman John P JP Maylie James J
Nature neuroscience 20080120 2
Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical properties of AMPA receptors (AMPARs). Small-conductance Ca(2+)-activated K(+) channels (SK2 channels) are functionally coupled with NMDA receptors (NMDARs) in CA1 spines such that their activity modulates the shape of excitatory postsynaptic potentials (EPSPs) and increases the threshold for induction of LTP. Here we show that LTP induction in mo ...[more]