Ontology highlight
ABSTRACT:
SUBMITTER: Li MH
PROVIDER: S-EPMC5436114 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Li Ming-Hua MH Underhill Suzanne M SM Reed Cheryl C Phillips Tamara J TJ Amara Susan G SG Ingram Susan L SL
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20161215 7
The psychostimulants amphetamine (AMPH) and methamphetamine (MA) are widely abused illicit drugs. Here we show that both psychostimulants acutely increase NMDA receptor (NMDAR)-mediated synaptic currents and decrease AMPA receptor (AMPAR)/NMDAR ratios in midbrain dopamine neurons. The potentiation depends on the transport of AMPH into the cell by the dopamine transporter. NMDAR-GluN2B receptor inhibitors, ifenprodil, RO 25-6981, and RO 04-5595, inhibit the potentiation without affecting basal-ev ...[more]