Ontology highlight
ABSTRACT:
SUBMITTER: Lee HJ
PROVIDER: S-EPMC2614748 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lee Heun Jin HJ Peterson Eric L EL Phillips Rob R Klug William S WS Wiggins Paul A PA
Proceedings of the National Academy of Sciences of the United States of America 20081201 49
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture detailed 3-dimensional conformations of membranes in cellular processes ranging from viral budding and organelle maintenance to phagocytosis. Despite the wealth of membrane structures available, there is as yet no generic, quantitative method fo ...[more]