Ontology highlight
ABSTRACT:
SUBMITTER: Margolis SS
PROVIDER: S-EPMC2967209 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Margolis Seth S SS Salogiannis John J Lipton David M DM Mandel-Brehm Caleigh C Wills Zachary P ZP Mardinly Alan R AR Hu Linda L Greer Paul L PL Bikoff Jay B JB Ho Hsin-Yi Henry HY Soskis Michael J MJ Sahin Mustafa M Greenberg Michael E ME
Cell 20101001 3
The mechanisms that promote excitatory synapse formation and maturation have been extensively studied. However, the molecular events that limit excitatory synapse development so that synapses form at the right time and place and in the correct numbers are less well understood. We have identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor tyrosine kinase triggers Ephexin5 phosphorylation ...[more]