Nickel-catalyzed asymmetric cross-couplings of racemic propargylic halides with arylzinc reagents.

ABSTRACT: A stereoconvergent method for the catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed. Neither family of compounds has previously been shown to be a suitable partner in such coupling processes. From a practical point of view, it is noteworthy that the catalyst components (NiCl2.glyme and pybox ligand 1) are commercially available.

SUBMITTER: Smith SW 

PROVIDER: S-EPMC2626171 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature