Ontology highlight
ABSTRACT:
SUBMITTER: Crouch PJ
PROVIDER: S-EPMC2626711 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Crouch Peter J PJ Hung Lin Wai LW Adlard Paul A PA Cortes Mikhalina M Lal Varsha V Filiz Gulay G Perez Keyla A KA Nurjono Milawaty M Caragounis Aphrodite A Du Tai T Laughton Katrina K Volitakis Irene I Bush Ashley I AI Li Qiao-Xin QX Masters Colin L CL Cappai Roberto R Cherny Robert A RA Donnelly Paul S PS White Anthony R AR Barnham Kevin J KJ
Proceedings of the National Academy of Sciences of the United States of America 20090102 2
Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of synaptotoxic amyloid-beta (Abeta) oligomers and hyperphosphorylated tau. Because recent evidence indicates that glycogen synthase kinase 3beta (GSK3beta) activity regulates these neurotoxic pathways, we developed an AD therapeutic strategy to target GSK3beta. The strategy involves the use of copper-bis(thiosemicarbazonoto) complexes to increase intracellular copper bioavailability and inhibit GSK3beta through act ...[more]