Properdin: New roles in pattern recognition and target clearance.
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ABSTRACT:
SUBMITTER: Kemper C
PROVIDER: S-EPMC2628304 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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Properdin: New roles in pattern recognition and target clearance.
Kemper Claudia C Hourcade Dennis E DE
Molecular immunology 20080808 16
Properdin was first described over 50 years ago by Louis Pillemer and his collaborators as a vital component of an antibody-independent complement activation pathway. In the 1970s properdin was shown to be a stabilizing component of the alternative pathway convertases, the central enzymes of the complement cascade. Recently we have reported that properdin can also bind to target cells and microbes, provide a platform for convertase assembly and function, and promote target phagocytosis. Evidence ...[more]
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