Ontology highlight
ABSTRACT:
SUBMITTER: Waldron TT
PROVIDER: S-EPMC2629216 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Waldron Travis T TT Springer Timothy A TA
Proceedings of the National Academy of Sciences of the United States of America 20081231 1
The selectins are cell adhesion proteins that must resist applied forces to mediate leukocyte tethering and rolling along the endothelium and have 2 conformational states. Selectin-ligand bond dissociation increases only modestly with applied force, and exhibits catch bond behavior in a low-force regime where bond lifetimes counterintuitively increase with increasing force. Both allosteric and sliding-rebinding models have emerged to explain catch bonds. Here, we introduce a large residue into a ...[more]