Ontology highlight
ABSTRACT:
SUBMITTER: Lu S
PROVIDER: S-EPMC2999562 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Lü Shouqin S Zhang Yan Y Long Mian M
PloS one 20101208 12
Allostery of P-selectin lectin (Lec) domain followed by an epithelial growth factor (EGF)-like domain is essential for its biological functionality, but the underlying pathways have not been well understood. Here the molecular dynamics simulations were performed on the crystallized structures to visualize the dynamic conformational change for state 1 (S1) or state 2 (S2) Lec domain with respective bent (B) or extended (E) EGF orientation. Simulations illustrated that both S1 and S2 conformations ...[more]