Ontology highlight
ABSTRACT:
SUBMITTER: Bestman JE
PROVIDER: S-EPMC2629308 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Bestman Jennifer E JE Cline Hollis T HT
Proceedings of the National Academy of Sciences of the United States of America 20081212 51
Visual system development requires experience-dependent mechanisms that regulate neuronal structure and function, including dendritic arbor growth, synapse formation, and stabilization. Although RNA binding proteins have been shown to affect some forms of synaptic plasticity in adult animals, their role in the development of neuronal structure and functional circuitry is not clear. Using two-photon time-lapse in vivo imaging and electrophysiology combined with morpholino-mediated knockdown and e ...[more]