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Nitric oxide administration using an oxygen hood: a pilot trial.

ABSTRACT: We have shown earlier that inhaled nitric oxide (iNO) administered by oxygen hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2)).Masked randomized controlled pilot trial. Inclusion criteria were: gestation>or=34 weeks, age<7 days, with post-ductal arterial line, and A-aDO(2) 400-600. Infants were randomized to study gas (iNO 20 ppm or equivalent O(2) flow) for 1 hr which was then weaned over the next 4 hours. Primary outcome was PaO(2) one hour post-randomization. Four infants each were randomized to iNO or O(2) (controls). Two of the four infants given iNO had an increase in PaO(2) of >100 torr, while oxygenation was unchanged in the controls. Methemoglobinemia and other adverse effects were not noted in any infant. Environmental levels of NO and NO(2) were minimal (<1 ppm) at >0.3 m from the hood.Administration of iNO by oxygen hood is feasible. Larger randomized controlled trials are required to measure the efficacy and determine an appropriate target population for this technique.ClinicalTrials.gov NCT00041548.

SUBMITTER: Ambalavanan N

PROVIDER: S-EPMC2629563 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Nitric oxide administration using an oxygen hood: a pilot trial.

Ambalavanan Namasivayam N El-Ferzli George T GT Roane Claire C Johnson Robert R Carlo Waldemar A WA

PloS one 20090202 2

<h4>Background</h4>We have shown earlier that inhaled nitric oxide (iNO) administered by oxygen hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2)).<h4>Methods/principal findings</h4>Masked randomized controlled pilot trial. Inclusion criteria were: gestation>or=34 weeks, age<7 days, with post-ductal arterial line, ...[more]

PMID: 19183804

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Nitric oxide administration using an oxygen hood: a pilot trial.

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Nitric oxide administration using an oxygen hood: a pilot trial.

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