Ontology highlight
ABSTRACT:
SUBMITTER: Pelkey KA
PROVIDER: S-EPMC2630456 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Pelkey Kenneth A KA Topolnik Lisa L Yuan Xiao-Qing XQ Lacaille Jean-Claude JC McBain Chris J CJ
Neuron 20081201 6
At hippocampal mossy fiber (MF)-st. lucidum interneuron (SLIN) synapses, mGluR7 serves as a metaplastic switch controlling bidirectional plasticity. mGluR7 activation during high-frequency stimulation (HFS) triggers presynaptic LTD due to persistent P/Q-type Ca(2+) channel inhibition. However, following mGluR7 internalization HFS produces presynaptic LTP. Surprisingly, LTP is not a simple molecular reversal of Ca(2+) channel depression. Rather, mGluR7 activation/internalization controls plastici ...[more]