Ontology highlight
ABSTRACT:
SUBMITTER: Sonoda T
PROVIDER: S-EPMC7512545 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Sonoda Takuma T Li Jennifer Y JY Hayes Nikolas W NW Chan Jonathan C JC Okabe Yudai Y Belin Stephane S Nawabi Homaira H Schmidt Tiffany M TM
Science (New York, N.Y.) 20200501 6490
Retinal ganglion cells (RGCs) drive diverse, light-evoked behaviors that range from conscious visual perception to subconscious, non-image-forming behaviors. It is thought that RGCs primarily drive these functions through the release of the excitatory neurotransmitter glutamate. We identified a subset of melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at non-image-forming brain targets. GABA release ...[more]