Ontology highlight
ABSTRACT:
SUBMITTER: Lu W
PROVIDER: S-EPMC2630518 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lu Wei W Zhu Huiping H Wen Shu S Yang Wei W Shaw Gary M GM Lammer Edward J EJ Finnell Richard H RH
Birth defects research. Part A, Clinical and molecular teratology 20081001 10
<h4>Background</h4>Moderate hyperhomocysteinemia is a known risk factor for NTDs in a variety of experimental model systems and is believed to be important in humans as well. The enzyme nicotinamide N-methyl transferase (NNMT) was identified in a genome-wide linkage scan as being an important regulator of homocysteine homeostasis in a Spanish population, making it an interesting candidate gene for NTDs.<h4>Methods</h4>We evaluated 11 SNPs (single nucleotide polymorphism) of the NNMT gene in our ...[more]